TME KNOWLEDGE

BRCA and BRCA-like Breast Cancers

          Triple negative (esp. BRCA1)

          Susceptible to DNA damaging agents like cisplatin

        BRCA deficient cells can’t repair double strand DNA breaks very well leading to death

          Poly ADP Ribose Polymerase (PARP) is secondary DNA repair mechanism

 

Project details

Tags: Pathway Targeted Therapy

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