Beginnings of Targeted Therapy

       Tamoxifen used to treat all breast cancers

       Estrogen Receptor discovered in mid 1970’s

       Horowitz, McGuire, et al. hypothesize that ER predicts response to endocrine therapy (Science, 1975; 189:726)

       NSABP B-14 all patients had ER testing

      ER pos - randomized to tamoxifen vs placebo




Project details

Tags: Pathway Targeted Therapy

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