TME KNOWLEDGE

ACOSOG Z11 Change in Practice

 

cN0 Breast Conservation Patients

  1. No Axillary Dissection if 1-2 + nodes
  2. No Axillary RT for  1-2 pos nodes

cN0 Breast Conservation Patients

  1. No Axillary Dissection if 1-2 pos nodes
  2. No Axillary RT for  1-2 pos nodes
  3. What about other groups of patients?
    1. BCS with 5-day APBI – no data
    2. Mastectomy – next study
  1. Pre-op sono with FNA
    1. only for >2 abnormal nodes
  2. Intra-op frozen section
    1. only >2 abnormal nodes

 

AMAROS Trial – ASCO 2013
(After Mapping Axilla, Radiotherapy or Surgery)

  1. 4,806 patients, cT1-2, cN0; median f/u = 6.1 yrs
  2. SN+ randomized: 744 ALND, 681 ART
  3. NSN+ (N1 - macro and micro): 40 %
  4. % Axillary Recurrence: 0.5 ALND, 1.0 ART
  5. % 5 yr OS: 93% for both ALND and ART
  6. % Lymphedema at 5 yrs: 28 ALND, 14 ART (p<0.0001)
 

 

Project details

Tags: Axillary Management

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