Cancer Biology: Opposing molecular pathways

Cancer Biology: Opposing molecular pathways

          Growth/proliferation vs Repair/Apoptosis

1. Genes & Genetic Testing: Advances/Challenges

2. Tumor Pathway Analysis: Treatment Choices

          Therapeutic Paradigm Shift

        Target the Pathway and Predicted Benefit

        (Choices based less and less on Stage)

Major Players


n  PI3K - Phosphoinositide 3-kinase

n  Akt - serine threonine specific protein kinase (“the Driver”)

n  mTOR - mammalian (mechanistic) target of rapamycin

n  ATM - ataxia telangiectasia mutated (“Lassie”)

n  PTEN - phosphatase and tensin homolog

n  RAD51 - radiation sensitive gene 51

n  PALB2 - partner and localizer of BRCA2

n  CHEK2 - CHK2 checkpoint homolog (“Timmy’s brother”)

n  BRIP1 - BRCA1-interacting protein 1

n  STK11 - serine threonine kinase 11

n  No Introduction Needed:

n  ER, HER2/ErbB, BRCA (“the Doctor”), p53 (“the Sheriff”)


Project details

Tags: Cancer Biology

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