TME KNOWLEDGE

Complete Sequencing of all Breast Cancer genes

743 families ≥ 3 Br/Ov Ca: 2,285 BRCA1/2 “Negative”

n  “Vast Majority of BRCA1/2 tests are NEGATIVE”

n  Other genes, Missed BRCA1/2s, more complex

n  NGS “resolved” 191 families (26%)

n  35% (66) BRCA1/2 (missed vs Index pt neg)

n  65% (125) Other genes:

n  CHEK2, PALB2, TP53, ATM, BARD1, BRIP1, CDH1, ABRAXAS, NBN, RAD51C, RAD51D, STK11, XRCC2

 

Project details

Tags: Genetics and Testing

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