TME KNOWLEDGE

Clinical Validation for DCIS Score

ECOG E5194 (Parent DCIS Study)

 

n  Prospective multicenter study 1997-2000 (n = 670)

 

n  Cohort 1:  Low/int. grade, < 2.5 cm

 

n  Cohort 2:  High grade, < 1 cm

 

n  No radiation

 

n  Resection -  minimum 3 mm negative margin

 

n  Tamoxifen option beginning May 2000 (29%)

 

n  Reports at 5 and 7 years (Hughes, JCO, 2009)

 

n  Currently 10-year outcomes

 

 

 

DCIS SCORE:  10-YEAR RISK OF AN
IPSILATERAL BREAST EVENT (IBE)

 

 

 

 

 

 

 

Summary:  DCIS Score

 

  • Valid:  DCIS Score predicts risk for an IBE
  • Independently predictive beyond traditional factors
    • (age, T size, grade, margin width, Tam)
  • Quantifies 10-year risk of  IBE
                    (Continuous variable or 3 risk groups)

 

 

Project details

Tags: Tumor Genomics

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