TME KNOWLEDGE

DCIS - ASCO - 2012 RTOG 9804 (2006; 6.5yrs)

n  Mammo, <2.5cm, low-int. G, 3mm margins

n  636 women randomized (original goal 1790)

n  (80% power to detect 6% vs 3.5% @ p = 0.05)

n  Tam in 62%

n  0.4% RT (2 pts) vs 3.2% OBS (15 pts) - (5yrs)

n  P = 0.0023

n  More toxicity with RT

 

DCIS Survival is nearly 100%
(generally missed occult invasive disease)
 - NIH Recommendations

 

n  Develop risk-stratification models to identify subsets of DCIS patients who need:

n  (1) Active surveillance only

n  (2) Local excision only

n  (3) Local excision with Radiotherapy

n  (4) Mastectomy

 

DCIS NCCN Guidelines

n  In 2008 NCCN Guidelines added

n  excision alone for DCIS

n  did not define the subset of patients

 

 

 

Project details

Tags: Tumor Genomics

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Vivamus molestie gravida turpis